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Self-organized cell motility from motor-filament interactions.

ABSTRACT: Cell motility is driven primarily by the dynamics of the cell cytoskeleton, a system of filamentous proteins and molecular motors. It has been proposed that cell motility is a self-organized process, that is, local short-range interactions determine much of the dynamics that are required for the whole-cell organization that leads to polarization and directional motion. Here we present a mesoscopic mean-field description of filaments, motors, and cell boundaries. This description gives rise to a dynamical system that exhibits multiple self-organized states. We discuss several qualitative aspects of the asymptotic states and compare them with those of living cells.

SUBMITTER: Du X

PROVIDER: S-EPMC3328710 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Self-organized cell motility from motor-filament interactions.

Du XinXin X Doubrovinski Konstantin K Osterfield Miriam M

Biophysical journal 20120401 8

Cell motility is driven primarily by the dynamics of the cell cytoskeleton, a system of filamentous proteins and molecular motors. It has been proposed that cell motility is a self-organized process, that is, local short-range interactions determine much of the dynamics that are required for the whole-cell organization that leads to polarization and directional motion. Here we present a mesoscopic mean-field description of filaments, motors, and cell boundaries. This description gives rise to a ...[more]

PMID: 22768929

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