Signaling-mediated bacterial persister formation.
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ABSTRACT:
SUBMITTER: Vega NM
PROVIDER: S-EPMC3329571 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Signaling-mediated bacterial persister formation.
Vega Nicole M NM Allison Kyle R KR Khalil Ahmad S AS Collins James J JJ
Nature chemical biology 20120318 5
Here we show that bacterial communication through indole signaling induces persistence, a phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic treatment. We monitor indole-induced persister formation using microfluidics and identify the role of oxidative-stress and phage-shock pathways in this phenomenon. We propose a model in which indole signaling 'inoculates' a bacterial subpopulation against antibiotics by activating stress responses, leading to persister for ...[more]
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