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ABSTRACT: Background
UK estimates of age related macular degeneration (AMD) occurrence vary.Aims
To estimate prevalence, number and incidence of AMD by type in the UK population aged ?50 years.Methods
Age-specific prevalence rates of AMD obtained from a Bayesian meta-analysis of AMD prevalence were applied to UK 2007-2009 population data. Incidence was estimated from modelled age-specific prevalence.Results
Overall prevalence of late AMD was 2.4% (95% credible interval (CrI) 1.7% to 3.3%), equivalent to 513?000 cases (95% CrI 363?000 to 699?000); estimated to increase to 679?000 cases by 2020. Prevalences were 4.8% aged ?65 years, 12.2% aged ?80 years. Geographical atrophy (GA) prevalence rates were 1.3% (95% CrI 0.9% to 1.9%), 2.6% (95% CrI 1.8% to 3.7%) and 6.7% (95% CrI 4.6% to 9.6%); neovascular AMD (NVAMD) 1.2% (95% CrI 0.9% to 1.7%), 2.5% (95% CrI 1.8% to 3.4%) and 6.3% (95% CrI 4.5% to 8.6%), respectively. The estimated number of prevalent cases of late AMD were 60% higher in women versus men (314?000 cases in women, 192?000 men). Annual incidence of late AMD, GA and NVAMD per 1000 women was 4.1 (95% CrI 2.4% to 6.8%), 2.4 (95% CrI 1.5% to 3.9%) and 2.3 (95% CrI 1.4% to 4.0%); in men 2.6 (95% CrI 1.5% to 4.4%), 1.7 (95% CrI 1.0% to 2.8%) and 1.4 (95% CrI 0.8% to 2.4%), respectively. 71?000 new cases of late AMD were estimated per year.Conclusions
These estimates will guide health and social service provision for those with late AMD and enable estimation of the cost of introducing new treatments.
SUBMITTER: Owen CG
PROVIDER: S-EPMC3329633 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Owen Christopher G CG Jarrar Zakariya Z Wormald Richard R Cook Derek G DG Fletcher Astrid E AE Rudnicka Alicja R AR
The British journal of ophthalmology 20120213 5
<h4>Background</h4>UK estimates of age related macular degeneration (AMD) occurrence vary.<h4>Aims</h4>To estimate prevalence, number and incidence of AMD by type in the UK population aged ≥50 years.<h4>Methods</h4>Age-specific prevalence rates of AMD obtained from a Bayesian meta-analysis of AMD prevalence were applied to UK 2007-2009 population data. Incidence was estimated from modelled age-specific prevalence.<h4>Results</h4>Overall prevalence of late AMD was 2.4% (95% credible interval (CrI ...[more]