Ontology highlight
ABSTRACT:
SUBMITTER: Lemmon SK
PROVIDER: S-EPMC3330156 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Lemmon Sandra K SK Traub Linton M LM
Traffic (Copenhagen, Denmark) 20120113 4
The N-terminal domain (TD) of the clathrin heavy chain is folded into a seven-bladed β-propeller that projects inward from the polyhedral outer clathrin coat. As the most membrane-proximal portion of assembled clathrin, the TD is a major protein-protein interaction node. Contact with the TD β-propeller occurs through short peptide sequences typically located within intrinsically disordered segments of coat components that usually are elements of the membrane-apposed, inner 'adaptor' coat layer. ...[more]