Ontology highlight
ABSTRACT:
SUBMITTER: Gould A
PROVIDER: S-EPMC3330704 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Gould Andrew A Li Yilong Y Majumder Subhabrata S Garcia Angie E AE Carlsson Patrick P Shekhtman Alexander A Camarero Julio A JA
Molecular bioSystems 20120210 4
Defensins are antimicrobial peptides that are important in the innate immune defense of mammals. In contrast to mammalian α- and β-defensins, rhesus θ-defensin-1 (RTD-1) comprises only 18 amino acids stabilized by three disulfide bonds and an unusual backbone cyclic topology. In this work we report for the first time the recombinant expression of the fully folded θ-defensin RTD-1 using a bacterial expression system. This was accomplished using an intramolecular native chemical ligation in combin ...[more]