Dataset Information

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

ABSTRACT: Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (? = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (? = 0.06-0.12 mmol/allele, P ? 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ? 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.

SUBMITTER: Scott RA

PROVIDER: S-EPMC3331745 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

Scott Robert A RA Chu Audrey Y AY Grarup Niels N Manning Alisa K AK Hivert Marie-France MF Shungin Dmitry D Tönjes Anke A Yesupriya Ajay A Barnes Daniel D Bouatia-Naji Nabila N Glazer Nicole L NL Jackson Anne U AU Kutalik Zoltán Z Lagou Vasiliki V Marek Diana D Rasmussen-Torvik Laura J LJ Stringham Heather M HM Tanaka Toshiko T Aadahl Mette M Arking Dan E DE Bergmann Sven S Boerwinkle Eric E Bonnycastle Lori L LL Bornstein Stefan R SR Brunner Eric E Bumpstead Suzannah J SJ Brage Soren S Carlson Olga D OD Chen Han H Chen Yii-Der Ida YD Chines Peter S PS Collins Francis S FS Couper David J DJ Dennison Elaine M EM Dowling Nicole F NF Egan Josephine S JS Ekelund Ulf U Erdos Michael R MR Forouhi Nita G NG Fox Caroline S CS Goodarzi Mark O MO Grässler Jürgen J Gustafsson Stefan S Hallmans Göran G Hansen Torben T Hingorani Aroon A Holloway John W JW Hu Frank B FB Isomaa Bo B Jameson Karen A KA Johansson Ingegerd I Jonsson Anna A Jørgensen Torben T Kivimaki Mika M Kovacs Peter P Kumari Meena M Kuusisto Johanna J Laakso Markku M Lecoeur Cécile C Lévy-Marchal Claire C Li Guo G Loos Ruth J F RJ Lyssenko Valeri V Marmot Michael M Marques-Vidal Pedro P Morken Mario A MA Müller Gabriele G North Kari E KE Pankow James S JS Payne Felicity F Prokopenko Inga I Psaty Bruce M BM Renström Frida F Rice Ken K Rotter Jerome I JI Rybin Denis D Sandholt Camilla H CH Sayer Avan A AA Shrader Peter P Schwarz Peter E H PE Siscovick David S DS Stancáková Alena A Stumvoll Michael M Teslovich Tanya M TM Waeber Gérard G Williams Gordon H GH Witte Daniel R DR Wood Andrew R AR Xie Weijia W Boehnke Michael M Cooper Cyrus C Ferrucci Luigi L Froguel Philippe P Groop Leif L Kao W H Linda WH Vollenweider Peter P Walker Mark M Watanabe Richard M RM Pedersen Oluf O Meigs James B JB Ingelsson Erik E Barroso Inês I Florez Jose C JC Franks Paul W PW Dupuis Josée J Wareham Nicholas J NJ Langenberg Claudia C

Diabetes 20120313 5

Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2- ...[more]

PMID: 22415877

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Project description:Physical activity (PA) and its health benefits are a continuous point of discussion. Recommendations for children's daily PA vary between guidelines. To better define the amount of PA necessary to prevent overweight and obesity in children, further research is needed. The present study investigates children's compliance to physical activity guidelines (PAGs) and the association between objectively measured PA and body mass index (BMI).Participating children were 11 years old (n = 419) and part of the European CHOP trial, which was conducted in Germany, Belgium, Poland, Spain, Italy. At least 2 days of PA measurements were collected from each child using a SenseWear™ armband. BMI was calculated from children's height and weight. Thresholds of min·day-1 in PA needed to differentiate between normal and excess weight (overweight/obesity) were determined with Receiver Operator Characteristics (ROC) analysis. Additionally, adjusted linear and logistic regressions models were calculated for group differences and effects of a 5, 15 and 60 min·day-1 increases in PA on BMI.Median time spent in total PA was 462 min·day-1 (25th percentile; 75th percentile: 389; 534) and 75 min·day-1 (41; 115) in moderate to vigorous PA (MVPA). Girls spent 36 min·day-1 less in MVPA than boys and overweight/obese children 24 min·day-1 less than normal weight children (linear regression, p < 0.001). 63.2% of the children met PAGs of 60 min·day-1 in MVPA. The optimal threshold for min·day-1 in MVPA determined with ROC analysis was 46 min·day-1. Comparing 5, 15 and 60 min·day-1 increases in PA revealed that an additional 15 min·day-1 of vigorous PA had the same effect as 60 min·day-1 of MVPA. Sedentary time and light PA showed contrary associations to one another, with light PA being negatively and sedentary time being positively associated with excessive weight.Current PAGs are met by 2/3 of children and seem appropriate to prevent excess weight in children. An official recommendation of daily 15-20 min of vigorous PA and further reduction of sedentary time could help to fight youth overweight and thus be of potential public health importance.ClinicalTrials.gov Identifier: NCT00338689 . Registered: June 19, 2006 (retrospectively registered).

Dataset Information

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

Publications

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

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