Ontology highlight
ABSTRACT:
SUBMITTER: Mikhaylova O
PROVIDER: S-EPMC3331999 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Mikhaylova Olga O Stratton Yiwen Y Hall Daniel D Kellner Emily E Ehmer Birgit B Drew Angela F AF Gallo Catherine A CA Plas David R DR Biesiada Jacek J Meller Jarek J Czyzyk-Krzeska Maria F MF
Cancer cell 20120401 4
The von Hippel-Lindau tumor-suppressor gene (VHL) is lost in most clear cell renal cell carcinomas (ccRCC). Here, using human ccRCC specimens, VHL-deficient cells, and xenograft models, we show that miR-204 is a VHL-regulated tumor suppressor acting by inhibiting macroautophagy, with MAP1LC3B (LC3B) as a direct and functional target. Of note, higher tumor grade of human ccRCC was correlated with a concomitant decrease in miR-204 and increase in LC3B levels, indicating that LC3B-mediated macroaut ...[more]