Ontology highlight
ABSTRACT:
SUBMITTER: Philmus B
PROVIDER: S-EPMC3332044 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Philmus Benjamin B Abdelwahed Sameh S Williams Howard J HJ Fenwick Michael K MK Ealick Steven E SE Begley Tadhg P TP
Journal of the American Chemical Society 20120309 11
Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR and MS and was identified as a triazine in which the pyrimidine ring was oxidatively degraded. A mechanism for toxoflavin degradation based on the identification of the enzymatic product and the recently determined crystal structure of toxoflavin lyase is proposed. ...[more]