Ontology highlight
ABSTRACT:
SUBMITTER: Ouna BA
PROVIDER: S-EPMC3332058 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ouna Benard A BA Nyambega Benson B Manful Theresa T Helbig Claudia C Males Matilda M Fadda Abeer A Clayton Christine C
PloS one 20120420 4
The Paf complex of Opisthokonts and plants contains at least five subunits: Paf1, Cdc73, Rtf1, Ctr9, and Leo1. Mutations in, or loss of Paf complex subunits have been shown to cause defects in histone modification, mRNA polyadenylation, and transcription by RNA polymerase I and RNA polymerase II. We here investigated trypanosome CTR9, which is essential for trypanosome survival. The results of tandem affinity purification suggested that trypanosome CTR9 associates with homologues of Leo1 and Cdc ...[more]