Ontology highlight
ABSTRACT:
SUBMITTER: Soderberg CA
PROVIDER: S-EPMC3332085 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Söderberg Christopher A G CA Shkumatov Alexander V AV Rajan Sreekanth S Gakh Oleksandr O Svergun Dmitri I DI Isaya Grazia G Al-Karadaghi Salam S
Journal of molecular biology 20111025 5
Frataxin is a mitochondrial protein with a central role in iron homeostasis. Defects in frataxin function lead to Friedreich's ataxia, a progressive neurodegenerative disease with childhood onset. The function of frataxin has been shown to be closely associated with its ability to form oligomeric species; however, the factors controlling oligomerization and the types of oligomers present in solution are a matter of debate. Using small-angle X-ray scattering, we found that Co(2+), glycerol, and a ...[more]