Diversity of HIV type 1 envelope (V3-V5) sequence in HIV type 1-infected Indian children.
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ABSTRACT:
SUBMITTER: Prakash SS
PROVIDER: S-EPMC3332366 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
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Diversity of HIV type 1 envelope (V3-V5) sequence in HIV type 1-infected Indian children.
Prakash Somi Sankaran SS Kalra Rajesh R Lodha Rakesh R Kabra Sushil K SK Luthra Kalpana K
AIDS research and human retroviruses 20110921 5
Abstract We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. This virus also had a longer V3 sequence with 37 amino acids, a GRGQ motif, and a methionine residue before it (AIIMS_307). A unique finding was the complete deletion of the V4 region ...[more]
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