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Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates.

ABSTRACT: A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01_AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01_AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01_AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.

SUBMITTER: Ng OT

PROVIDER: S-EPMC3332370 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates.

Ng Oon Tek OT Eyzaguirre Lindsay M LM Carr Jean K JK Chew Kuan Kiat KK Lin Li L Chua Arlene A Leo Yee Sin YS Redd Andrew D AD Quinn Thomas C TC Laeyendecker Oliver O

AIDS research and human retroviruses 20110923 5

A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01_AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01_AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01_AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically ...[more]

PMID: 21902588

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