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Design, synthesis, and biological action of 20R-hydroxyvitamin D3.

ABSTRACT: The non-naturally occurring 20R epimer of 20-hydroxyvitamin D3 is synthesized based on chemical design and hypothesis. The 20R isomer is separated by semipreparative HPLC, and its structure is characterized. A comparison of 20R isomer to its 20S counterpart in biological evaluation demonstrates that they have different behaviors in antiproliferative and metabolic studies.

SUBMITTER: Lu Y

PROVIDER: S-EPMC3332540 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Design, synthesis, and biological action of 20R-hydroxyvitamin D3.

Lu Yan Y Chen Jianjun J Janjetovic Zorica Z Michaels Phillip P Tang Edith K Y EK Wang Jin J Tuckey Robert C RC Slominski Andrzej T AT Li Wei W Miller Duane D DD

Journal of medicinal chemistry 20120320 7

The non-naturally occurring 20R epimer of 20-hydroxyvitamin D3 is synthesized based on chemical design and hypothesis. The 20R isomer is separated by semipreparative HPLC, and its structure is characterized. A comparison of 20R isomer to its 20S counterpart in biological evaluation demonstrates that they have different behaviors in antiproliferative and metabolic studies. ...[more]

PMID: 22404326

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