Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC3332540 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Lu Yan Y Chen Jianjun J Janjetovic Zorica Z Michaels Phillip P Tang Edith K Y EK Wang Jin J Tuckey Robert C RC Slominski Andrzej T AT Li Wei W Miller Duane D DD
Journal of medicinal chemistry 20120320 7
The non-naturally occurring 20R epimer of 20-hydroxyvitamin D3 is synthesized based on chemical design and hypothesis. The 20R isomer is separated by semipreparative HPLC, and its structure is characterized. A comparison of 20R isomer to its 20S counterpart in biological evaluation demonstrates that they have different behaviors in antiproliferative and metabolic studies. ...[more]