Ontology highlight
ABSTRACT:
SUBMITTER: Pettersen JS
PROVIDER: S-EPMC3334331 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Pettersen Julia S JS Fuentes-Duculan Judilyn J Suárez-Fariñas Mayte M Pierson Katherine C KC Pitts-Kiefer Alexander A Fan Linda L Belkin Daniel A DA Wang Claire Q F CQ Bhuvanendran Shivaprasad S Johnson-Huang Leanne M LM Bluth Mark J MJ Krueger James G JG Lowes Michelle A MA Carucci John A JA
The Journal of investigative dermatology 20110210 6
Tumor-associated macrophages (TAMs) may have an important role in tumor immunity. We studied the activation state of TAMs in cutaneous SCC, the second most common human cancer. CD163 was identified as a more abundant, sensitive, and accurate marker of TAMs when compared with CD68. CD163(+) TAMs produced protumoral factors, matrix metalloproteinases 9 and 11 (MMP9 and MMP11), at the gene and protein levels. Gene set enrichment analysis (GSEA) was used to evaluate M1 and M2 macrophage gene sets in ...[more]