Ontology highlight
ABSTRACT:
SUBMITTER: McDonel P
PROVIDER: S-EPMC3334623 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
McDonel Patrick P Demmers Jeroen J Tan David W M DW Watt Fiona F Hendrich Brian D BD
Developmental biology 20111220 1
The Sin3a/HDAC co-repressor complex is a critical regulator of transcription networks that govern cell cycle control and apoptosis throughout development. Previous studies have identified Sin3a as essential for embryonic development around the time of implantation, during which the epiblast cell cycle is uniquely structured to achieve very rapid divisions with little tolerance of DNA damage. This study investigates the specific requirement for Sin3a in the early mouse embryo and shows that embry ...[more]