Ontology highlight
ABSTRACT:
SUBMITTER: Jackman JE
PROVIDER: S-EPMC3334698 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Jackman Jane E JE Gott Jonatha M JM Gray Michael W MW
RNA (New York, N.Y.) 20120328 5
The tRNA(His) guanylyltransferase (Thg1) family of enzymes comprises members from all three domains of life (Eucarya, Bacteria, Archaea). Although the initial activity associated with Thg1 enzymes was a single 3'-to-5' nucleotide addition reaction that specifies tRNA(His) identity in eukaryotes, the discovery of a generalized base pair-dependent 3'-to-5' polymerase reaction greatly expanded the scope of Thg1 family-catalyzed reactions to include tRNA repair and editing activities in bacteria, ar ...[more]