Ontology highlight
ABSTRACT:
SUBMITTER: McEwan DL
PROVIDER: S-EPMC3334877 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Cell host & microbe 20120401 4
Intestinal epithelial cells are exposed to both innocuous and pathogenic microbes, which need to be distinguished to mount an effective immune response. To understand the mechanisms underlying pathogen recognition, we investigated how Pseudomonas aeruginosa triggers intestinal innate immunity in Caenorhabditis elegans, a process independent of Toll-like pattern recognition receptors. We show that the P. aeruginosa translational inhibitor Exotoxin A (ToxA), which ribosylates elongation factor 2 ( ...[more]