Ontology highlight
ABSTRACT:
SUBMITTER: Gomez CE
PROVIDER: S-EPMC3334902 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Gómez Carmen Elena CE Perdiguero Beatriz B Jiménez Victoria V Filali-Mouhim Abdelali A Ghneim Khader K Haddad Elias K EK Quakkelaar Esther D ED Delaloye Julie J Harari Alexandre A Roger Thierry T Duhen Thomas T Sékaly Rafick P RP Melief Cornelis J M CJ Calandra Thierry T Sallusto Federica F Lanzavecchia Antonio A Wagner Ralf R Pantaleo Giuseppe G Esteban Mariano M
PloS one 20120419 4
Based on the partial efficacy of the HIV/AIDS Thai trial (RV144) with a canarypox vector prime and protein boost, attenuated poxvirus recombinants expressing HIV-1 antigens are increasingly sought as vaccine candidates against HIV/AIDS. Here we describe using systems analysis the biological and immunological characteristics of the attenuated vaccinia virus Ankara strain expressing the HIV-1 antigens Env/Gag-Pol-Nef of HIV-1 of clade C (referred as MVA-C). MVA-C infection of human monocyte derive ...[more]