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Engaging neuroscience to advance translational research in brain barrier biology.

ABSTRACT: The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

SUBMITTER: Neuwelt EA

PROVIDER: S-EPMC3335275 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Engaging neuroscience to advance translational research in brain barrier biology.

Neuwelt Edward A EA Bauer Björn B Fahlke Christoph C Fricker Gert G Iadecola Constantino C Janigro Damir D Leybaert Luc L Molnár Zoltán Z O'Donnell Martha E ME Povlishock John T JT Saunders Norman R NR Sharp Frank F Stanimirovic Danica D Watts Ryan J RJ Drewes Lester R LR

Nature reviews. Neuroscience 20110301 3

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and--when barrier integrity is impaired--in the pathology of many common CNS disorders such as Alz ...[more]

PMID: 21331083

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