Ontology highlight
ABSTRACT:
SUBMITTER: Dao KL
PROVIDER: S-EPMC3335367 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Bioconjugate chemistry 20120404 4
As part of our program to develop breast cancer specific therapeutic agents, we have synthesized a conjugate agent that is a conjugate of the steroidal anti-estrogen and the potent cytotoxin doxorubicin. In this effort, we employed a modular assembly approach to prepare a novel 11β-substituted steroidal anti-estrogen functionalized with an azido-tetraethylene glycol moiety, which could be coupled to a complementary doxorubicin benzoyl hydrazone functionalized with a propargyl tetraethylene glyco ...[more]