Ontology highlight
ABSTRACT:
SUBMITTER: Izquierdo-Useros N
PROVIDER: S-EPMC3335875 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Izquierdo-Useros Nuria N Lorizate Maier M Contreras F-Xabier FX Rodriguez-Plata Maria T MT Glass Bärbel B Erkizia Itziar I Prado Julia G JG Casas Josefina J Fabriàs Gemma G Kräusslich Hans-Georg HG Martinez-Picado Javier J
PLoS biology 20120424 4
HIV-1 is internalized into mature dendritic cells (mDCs) via an as yet undefined mechanism with subsequent transfer of stored, infectious virus to CD4+ T lymphocytes. Thus, HIV-1 subverts a DC antigen capture mechanism to promote viral spread. Here, we show that gangliosides in the HIV-1 membrane are the key molecules for mDC uptake. HIV-1 virus-like particles and liposomes mimicking the HIV-1 lipid composition were shown to use a common internalization pathway and the same trafficking route wit ...[more]