Siglecs as sensors of self in innate and adaptive immune responses.
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ABSTRACT:
SUBMITTER: Paulson JC
PROVIDER: S-EPMC3335958 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Siglecs as sensors of self in innate and adaptive immune responses.
Paulson James C JC Macauley Matthew S MS Kawasaki Norihito N
Annals of the New York Academy of Sciences 20120130
Siglecs are expressed on most white blood cells of the immune system and are known to modulate the activity of cell signaling receptors via regulatory motifs in their cytoplasmic domains. This immunoglobulin subfamily of coreceptors recognize sialic acid containing glycans as ligands, which are found on glycoproteins and glycolipids of all mammalian cells. By virtue of their ability to recognize this common structural element, siglecs are increasingly recognized for their ability to help immune ...[more]
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