Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee SR
PROVIDER: S-EPMC3336105 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Banerjee Sangeeta R SR Foss Catherine A CA Castanares Mark M Mease Ronnie C RC Byun Youngjoo Y Fox James J JJ Hilton John J Lupold Shawn E SE Kozikowski Alan P AP Pomper Martin G MG
Journal of medicinal chemistry 20080719 15
The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target for imaging and therapy of cancer. We prepared seven (99m)Tc/Re-labeled compounds by attaching known Tc/Re chelating agents to an amino-functionalized PSMA inhibitor (lys-NHCONH-glu) with or without a variable length linker moiety. K i values ranged from 0.17 to 199 nM. Ex vivo biodistribution and in vivo imaging demonstrated the degree of specific binding to engineered PSMA+ PC3 PIP tumors. PC3-PIP cells ...[more]