MTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
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ABSTRACT:
SUBMITTER: Peterson TR
PROVIDER: S-EPMC3336367 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Peterson Timothy R TR Sengupta Shomit S SS Harris Thurl E TE Carmack Anne E AE Kang Seong A SA Balderas Eric E Guertin David A DA Madden Katherine L KL Carpenter Anne E AE Finck Brian N BN Sabatini David M DM
Cell 20110801 3
The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy, and lipogenesis. Through unknown mechanisms, mTORC1 promotes the function of SREBP, a master regulator of lipo- and sterolgenic gene transcription. Here, we demonstrate that mTORC1 regulates SREBP by controlling the nuclear entry of lipin 1, a phosphatidic acid phosphatase. Dephosphorylated, nuclear, catalytically active lipin 1 promotes ...[more]
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