Ontology highlight
ABSTRACT:
SUBMITTER: Dam DH
PROVIDER: S-EPMC3337354 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
ACS nano 20120322 4
We report the direct visualization of interactions between drug-loaded nanoparticles and the cancer cell nucleus. Nanoconstructs composed of nucleolin-specific aptamers and gold nanostars were actively transported to the nucleus and induced major changes to the nuclear phenotype via nuclear envelope invaginations near the site of the construct. The number of local deformations could be increased by ultrafast, light-triggered release of the aptamers from the surface of the gold nanostars. Cancer ...[more]