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Polymorphisms and haplotypes in candidate genes related to angiogenesis and endothelial dysfunction in preeclampsia.


ABSTRACT: Valenzuela and colleagues have recently reviewed some polymorphisms in important candidate genes involved in different pathogenic mechanisms related to preeclampsia (PE) and concluded that various studies in different populations have identified maternal polymorphisms associated with PE. However, we would like to contribute to some studies regarding candidate genes related to angiogenesis and endothelial dysfunction in PE performed in the Brazilian population. Specifically, genotypes and haplotypes formed by polymorphisms of VEGF, eNOS and MMP-9, along with an example of the interaction among these genes in the prediction of PE. Our suggestions may provide additional information with clinical relevance to PE susceptibility.

SUBMITTER: Luizon MR 

PROVIDER: S-EPMC3337617 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Polymorphisms and haplotypes in candidate genes related to angiogenesis and endothelial dysfunction in preeclampsia.

Luizon Marcelo Rizzatti MR   Palei Ana Carolina Taveiros AC   Sandrim Valeria Cristina VC  

Journal of pregnancy 20120405


Valenzuela and colleagues have recently reviewed some polymorphisms in important candidate genes involved in different pathogenic mechanisms related to preeclampsia (PE) and concluded that various studies in different populations have identified maternal polymorphisms associated with PE. However, we would like to contribute to some studies regarding candidate genes related to angiogenesis and endothelial dysfunction in PE performed in the Brazilian population. Specifically, genotypes and haploty  ...[more]

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