Ontology highlight
ABSTRACT:
SUBMITTER: Santo L
PROVIDER: S-EPMC3337713 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Santo Loredana L Hideshima Teru T Kung Andrew L AL Tseng Jen-Chieh JC Tamang David D Yang Min M Jarpe Matthew M van Duzer John H JH Mazitschek Ralph R Ogier Walter C WC Cirstea Diana D Rodig Scott S Eda Homare H Scullen Tyler T Canavese Miriam M Bradner James J Anderson Kenneth C KC Jones Simon S SS Raje Noopur N
Blood 20120119 11
Histone deacetylase (HDAC) enzymatic activity has been linked to the transcription of DNA in cancers including multiple myeloma (MM). Therefore, HDAC inhibitors used alone and in combination are being actively studied as novel therapies in MM. In the present study, we investigated the preclinical activity of ACY-1215, an HDAC6-selective inhibitor, alone and in combination with bortezomib in MM. Low doses of ACY-1215 combined with bortezomib triggered synergistic anti-MM activity, resulting in pr ...[more]