Ontology highlight
ABSTRACT:
SUBMITTER: Feng Q
PROVIDER: S-EPMC3337775 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Feng QiPing Q Wilke Russell A RA Baye Tesfaye M TM
Pharmacogenomics 20120401 5
Skeletal muscle toxicity is the primary adverse effect of statins. In this review, we summarize current knowledge regarding the genetic and nongenetic determinants of risk for statin induced myopathy. Many genetic factors were initially identified through candidate gene association studies limited to pharmacokinetic (PK) targets. Through genome-wide association studies, it has become clear that SLCO1B1 is among the strongest PK predictors of myopathy risk. Genome-wide association studies have al ...[more]