Dataset Information
PINALOG: a novel approach to align protein interaction networks--implications for complex detection and function prediction.
Ontology highlight
ABSTRACT: Motivation
Analysis of protein-protein interaction networks (PPINs) at the system level has become increasingly important in understanding biological processes. Comparison of the interactomes of different species not only provides a better understanding of species evolution but also helps with detecting conserved functional components and in function prediction. Method andResults
Here we report a PPIN alignment method, called PINALOG, which combines information from protein sequence, function and network topology. Alignment of human and yeast PPINs reveals several conserved subnetworks between them that participate in similar biological processes, notably the proteasome and transcription related processes. PINALOG has been tested for its power in protein complex prediction as well as function prediction. Comparison with PSI-BLAST in predicting protein function in the twilight zone also shows that PINALOG is valuable in predicting protein function.Availability and implementation
The PINALOG web-server is freely available from http://www.sbg.bio.ic.ac.uk/~pinalog. The PINALOG program and associated data are available from the Download section of the web-server.Contact
m.sternberg@imperial.ac.ukSupplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Phan HT
PROVIDER: S-EPMC3338015 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
PINALOG: a novel approach to align protein interaction networks--implications for complex detection and function prediction.
Bioinformatics (Oxford, England) 20120313 9
<h4>Motivation</h4>Analysis of protein-protein interaction networks (PPINs) at the system level has become increasingly important in understanding biological processes. Comparison of the interactomes of different species not only provides a better understanding of species evolution but also helps with detecting conserved functional components and in function prediction. Method and<h4>Results</h4>Here we report a PPIN alignment method, called PINALOG, which combines information from protein seque ...[more]