Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe.
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ABSTRACT:
SUBMITTER: Yu C
PROVIDER: S-EPMC3338267 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
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Remarkably high rate of DNA amplification promoted by the mating-type switching mechanism in Schizosaccharomyces pombe.
Yu Chuanhe C Bonaduce Michael J MJ Klar Amar J S AJ
Genetics 20120229 1
A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and homologous recombination might be the general mechanisms for local genome region expansion. ...[more]
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