Ontology highlight
ABSTRACT:
SUBMITTER: Yokoo R
PROVIDER: S-EPMC3339199 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Yokoo Rayka R Zawadzki Karl A KA Nabeshima Kentaro K Drake Melanie M Arur Swathi S Villeneuve Anne M AM
Cell 20120301 1
Crossovers (COs) between homologous chromosomes ensure their faithful segregation during meiosis. We identify C. elegans COSA-1, a cyclin-related protein conserved in metazoa, as a key component required to convert meiotic double-strand breaks (DSBs) into COs. During late meiotic prophase, COSA-1 localizes to foci that correspond to the single CO site on each homolog pair and indicate sites of eventual concentration of other conserved CO proteins. Chromosomes gain and lose competence to load CO ...[more]