Standard Error of Empirical Bayes Estimate in NONMEM® VI.
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ABSTRACT:
SUBMITTER: Kang D
PROVIDER: S-EPMC3339294 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Standard Error of Empirical Bayes Estimate in NONMEM® VI.
Kang Dongwoo D Bae Kyun-Seop KS Houk Brett E BE Savic Radojka M RM Karlsson Mats O MO
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20120424 2
The pharmacokinetics/pharmacodynamics analysis software NONMEM® output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. A simple and direct method for estimating standard error of the empirical Bayes estimates of inter-subject variability using the NONMEM® VI internal matrix POSTV is developed and applied to several pharmacokinetic models using intensively or sparsely sampled ...[more]
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