Transient phenomena in gene expression after induction of transcription.
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ABSTRACT:
SUBMITTER: Deneke C
PROVIDER: S-EPMC3339862 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Transient phenomena in gene expression after induction of transcription.
Deneke Carlus C Rudorf Sophia S Valleriani Angelo A
PloS one 20120423 4
When transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, ribosomal profiles, and rate of protein synthesis. Our studies reveal that transient phenomena in gene expression strongly depend on the specific form of the mRNA lifetime distribution. ...[more]
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