Ontology highlight
ABSTRACT:
SUBMITTER: Roberts MA
PROVIDER: S-EPMC3340030 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Roberts Mark A J MA Wadhams George H GH Hadfield Katie A KA Tickner Susan S Armitage Judith P JP
Proceedings of the National Academy of Sciences of the United States of America 20120410 17
Recent data have shown that plasmid partitioning Par-like systems are used by some bacterial cells to control localization of protein complexes. Here we demonstrate that one of these homologs, PpfA, uses nonspecific chromosome binding to separate cytoplasmic clusters of chemotaxis proteins upon division. Using fluorescent microscopy and point mutations, we show dynamic chromosome binding and Walker-type ATPase activity are essential for cluster segregation. The N-terminal domain of a cytoplasmic ...[more]