Ontology highlight
ABSTRACT:
SUBMITTER: Edris B
PROVIDER: S-EPMC3340056 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Edris Badreddin B Weiskopf Kipp K Volkmer Anne K AK Volkmer Jens-Peter JP Willingham Stephen B SB Contreras-Trujillo Humberto H Liu Jie J Majeti Ravindra R West Robert B RB Fletcher Jonathan A JA Beck Andrew H AH Weissman Irving L IL van de Rijn Matt M
Proceedings of the National Academy of Sciences of the United States of America 20120326 17
Antibodies against CD47, which block tumor cell CD47 interactions with macrophage signal regulatory protein-α, have been shown to decrease tumor size in hematological and epithelial tumor models by interfering with the protection from phagocytosis by macrophages that intact CD47 bestows upon tumor cells. Leiomyosarcoma (LMS) is a tumor of smooth muscle that can express varying levels of colony-stimulating factor-1 (CSF1), the expression of which correlates with the numbers of tumor-associated ma ...[more]