Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
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ABSTRACT:
SUBMITTER: Kerkhofs J
PROVIDER: S-EPMC3340393 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
Kerkhofs Johan J Roberts Scott J SJ Luyten Frank P FP Van Oosterwyck Hans H Geris Liesbet L
PloS one 20120430 4
During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a fi ...[more]
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