Morphine activates neuroinflammation in a manner parallel to endotoxin.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC3341002 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
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Morphine activates neuroinflammation in a manner parallel to endotoxin.
Wang Xiaohui X Loram Lisa C LC Ramos Khara K de Jesus Armando J AJ Thomas Jacob J Cheng Kui K Reddy Anireddy A Somogyi Andrew A AA Hutchinson Mark R MR Watkins Linda R LR Yin Hang H
Proceedings of the National Academy of Sciences of the United States of America 20120402 16
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors. Herein, we provide direct evidence that morphine creates neuroinflammation via the activation of an innate immune receptor and not via classic opioid receptors. We demonstrate that morphine binds to an accessory protein of Toll-like receptor 4 (TLR4), myeloid differentiat ...[more]
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