Ontology highlight
ABSTRACT:
SUBMITTER: Malik M
PROVIDER: S-EPMC3341024 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Malik Mariam M Jividen Kasey K Padmakumar V C VC Cataisson Christophe C Li Luowei L Lee Jessica J Howard O M Zack OM Yuspa Stuart H SH
Proceedings of the National Academy of Sciences of the United States of America 20120402 16
Nuclear translocation of cytosolic CLIC4 is an essential feature of its proapoptotic and prodifferentiation functions. Here we demonstrate that CLIC4 is induced concurrently with inducible nitric oxide synthase (iNOS) and S-nitrosylated in proinflammatory peritoneal macrophages. Chemical inhibition or genetic ablation of iNOS inhibits S-nitrosylation and nuclear translocation of CLIC4. In macrophages, iNOS-induced nuclear CLIC4 coincides with the pro- to anti-inflammatory transition of the cells ...[more]