Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez GP
PROVIDER: S-EPMC3341054 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Rodriguez Gina P GP Romanova Nina V NV Bao Gaobin G Rouf N Cynthia NC Kow Yoke Wah YW Crouse Gray F GF
Proceedings of the National Academy of Sciences of the United States of America 20120402 16
Mismatch repair (MMR) is a major DNA repair pathway in cells from all branches of life that removes replication errors in a strand-specific manner, such that mismatched nucleotides are preferentially removed from the newly replicated strand of DNA. Here we demonstrate a role for MMR in helping create new phenotypes in nondividing cells. We show that mispairs in yeast that escape MMR during replication can later be subject to MMR activity in a replication strand-independent manner in nondividing ...[more]