Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC3341551 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Li Liren L Louch William E WE Niederer Steven A SA Aronsen Jan M JM Christensen Geir G Sejersted Ole M OM Smith Nicolas P NP
Biophysical journal 20120501 9
In cardiomyocytes, a major decrease in the level of sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) can severely impair systolic and diastolic functions. In mice with cardiomyocyte-specific conditional excision of the Serca2 gene (SERCA2 KO), end-stage heart failure developed between four and seven weeks after gene deletion combined with [Na(+)](i) elevation and intracellular acidosis. In this study, to investigate the underpinning changes in Ca(2+) dynamics and metabolic homeostasis, we devel ...[more]