Evolutionary conservation and network structure characterize genes of phenotypic relevance for mitosis in human.

ABSTRACT: The impact of gene silencing on cellular phenotypes is difficult to establish due to the complexity of interactions in the associated biological processes and pathways. A recent genome-wide RNA knock-down study both identified and phenotypically characterized a set of important genes for the cell cycle in HeLa cells. Here, we combine a molecular interaction network analysis, based on physical and functional protein interactions, in conjunction with evolutionary information, to elucidate the common biological and topological properties of these key genes. Our results show that these genes tend to be conserved with their corresponding protein interactions across several species and are key constituents of the evolutionary conserved molecular interaction network. Moreover, a group of bistable

SUBMITTER: Ostaszewski M 

PROVIDER: S-EPMC3342260 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature