Ontology highlight
ABSTRACT:
SUBMITTER: Smith AJ
PROVIDER: S-EPMC3342309 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
International journal for parasitology 20120313 4
The NIMA-related serine/threonine kinases (Neks) function in the cell cycle and regulate ciliary and flagellar length. The Giardia lamblia genome encodes 198 Neks, of which 56 are predicted to be active. Here we believe that we report the first functional analysis of two G. lamblia Neks. The GlNek1 and GlNek2 kinase domains share 57% and 43% identity to the kinase domains of human Nek1 and Nek2, respectively. Both GlNeks are active in vitro, have dynamic relocalisation during the cell cycle, and ...[more]