Ontology highlight
ABSTRACT:
SUBMITTER: Handa P
PROVIDER: S-EPMC3342311 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Handa Priya P Tateya Sanshiro S Rizzo Norma O NO Cheng Andrew M AM Morgan-Stevenson Vicki V Han Chang-Yeop CY Clowes Alexander W AW Daum Guenter G O'Brien Kevin D KD Schwartz Michael W MW Chait Alan A Kim Francis F
Arteriosclerosis, thrombosis, and vascular biology 20110908 12
<h4>Objective</h4>Obesity is characterized by chronic inflammation of adipose tissue, which contributes to insulin resistance and diabetes. Although nitric oxide (NO) signaling has antiinflammatory effects in the vasculature, whether reduced NO contributes to adipose tissue inflammation is unknown. We sought to determine whether (1) obesity induced by high-fat (HF) diet reduces endothelial nitric oxide signaling in adipose tissue, (2) reduced endothelial nitric oxide synthase (eNOS) signaling is ...[more]