Ontology highlight
ABSTRACT:
SUBMITTER: Hardin Narayan AR
PROVIDER: S-EPMC3342682 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20111109 1
Indolizinones are under-explored N-heterocycles that react with exquisite chemo- and stereoselectivity. An exploration of the fundamental reactivity of these azabicycles demonstrates the potential to relay stereochemical information from the ring-fusion to newly formed stereocenters on the bicyclic core. The indolizinone diene undergoes selective hydrogenation and readily participates in Diels-Alder cycloadditions as well as ene reactions. The vinylogous amide embedded in the five-membered ring ...[more]