Ontology highlight
ABSTRACT:
SUBMITTER: Miller EH
PROVIDER: S-EPMC3343336 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Miller Emily Happy EH Obernosterer Gregor G Raaben Matthijs M Herbert Andrew S AS Deffieu Maika S MS Krishnan Anuja A Ndungo Esther E Sandesara Rohini G RG Carette Jan E JE Kuehne Ana I AI Ruthel Gordon G Pfeffer Suzanne R SR Dye John M JM Whelan Sean P SP Brummelkamp Thijn R TR Chandran Kartik K
The EMBO journal 20120306 8
Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite considerable efforts, no essential cellular receptors for filovirus entry have been identified. We showed previously that Niemann-Pick C1 (NPC1), a lysosomal cholesterol transporter, is required for filovirus entry. Here, we demonstrate that NPC1 is a critical filovirus receptor. Human NPC1 fulfills a cardinal property of viral receptors: it confers susceptibility to filovirus infection when expressed in non-perm ...[more]