Ontology highlight
ABSTRACT:
SUBMITTER: Lackner DH
PROVIDER: S-EPMC3343340 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Lackner Daniel H DH Raices Marcela M Maruyama Hugo H Haggblom Candy C Karlseder Jan J
The EMBO journal 20120316 8
To counteract replication-dependent telomere shortening most eukaryotic cells rely on the telomerase pathway, which is crucial for the maintenance of proliferative potential of germ and stem cell populations of multicellular organisms. Likewise, cancer cells usually engage the telomerase pathway for telomere maintenance to gain immortality. However, in ∼10% of human cancers telomeres are maintained through telomerase-independent alternative lengthening of telomeres (ALT) pathways. Here, we descr ...[more]