Ontology highlight
ABSTRACT:
SUBMITTER: Gillich A
PROVIDER: S-EPMC3343665 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Gillich Astrid A Bao Siqin S Grabole Nils N Hayashi Katsuhiko K Trotter Matthew W B MW Pasque Vincent V Magnúsdóttir Erna E Surani M Azim MA
Cell stem cell 20120401 4
Epigenetic reprogramming in early germ cells is critical toward the establishment of totipotency, but investigations of the germline events are intractable. An objective cell culture-based system could provide mechanistic insight on how the key determinants of primordial germ cells (PGCs), including Prdm14, induce reprogramming in germ cells to an epigenetic ground state. Here we show a Prdm14-Klf2 synergistic effect that can accelerate and enhance reversion of mouse epiblast stem cells (epiSCs) ...[more]