Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study.

ABSTRACT:

Objectives

To determine the cross-sectional and longitudinal associations between 25-hydroxyvitamin D (25(OH)D) levels and frailty status in older men.

Design

Prospective cohort study.

Setting

Six U.S. community-based centers.

Participants

One thousand six hundred six men aged 65 and older.

Measurements

25(OH)D (liquid chromatography tandem mass spectroscopy) and frailty status (criteria similar to those used in the Cardiovascular Health Study) measured at baseline; frailty status assessment repeated an average of 4.6 years later. Frailty status was classified as robust, intermediate, or frail at baseline and robust, intermediate, frail, or dead at follow-up.

Results

After adjusting for multiple potential confounders, men with 25(OH)D levels less

SUBMITTER: Ensrud KE 

PROVIDER: S-EPMC3343694 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature