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(1Z,2E)-N'-{2-Chloro-1-methyl-2-[2-(4-methyl-phen-yl)hydrazin-1-yl-idene]ethyl-idene}-4-meth-oxy-benzohydrazide.

ABSTRACT: The asymmetric unit of the title compound, C(18)H(19)ClN(4)O(2), contains two mol-ecules, in which the dihedral angles between the benzene rings are 43.60 (12) and 58.65 (13)°. The hydrazine N atoms are twisted slightly out of the planes of the tolyl and meth-oxy-benzene rings: the C-C-N-N and N-N-C-C torsion angles are 171.1 (2) and -174.4 (2)°, respectively, for one mol-ecule and -177.4 (2) and -170.6 (2)°, respectively, for the other. In the crystal, mol-ecules are linked by N-H⋯O and C-H⋯O hydrogen bonds into chains propagating along the b-axis direction.

SUBMITTER: Abdel-Aziz HA

PROVIDER: S-EPMC3343910 | biostudies-literature |

REPOSITORIES: biostudies-literature

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(1Z,2E)-N'-{1-[2-(4-Bromo-phen-yl)hydrazin-1-yl-idene]-1-chloro-propan-2-yl-idene}thio-phene-2-carbohydrazide.

Project description:In the title compound, C(14)H(12)BrClN(4)OS, the thienyl ring is disordered over two orientations with a site-occupancy ratio of 0.853?(2):0.147?(2). The mol-ecule is roughly planar, with the dihedral angles between the thienyl and benzene rings being 6.24?(16) and 9.7?(11)° for the major and minor components, respectively. The central fragment is almost planar [r.m.s. deviation = 0.0275?(2)?Å for the ten non-H atoms]. The mean plane through this middle unit makes a dihedral angle of 2.71?(7)° with the benzene ring, whereas these values are 4.46?(15) and 7.7?(11)° for the major and minor components of the thienyl ring, respectively. In the crystal, mol-ecules are linked into dimers by pairs of N-H?O hydrogen bonds, forming R(2) (2)(8) ring motifs. These dimers are arranged into sheets parallel to the ac plane.

| S-EPMC3344617 | biostudies-literature

2-[(1E)-[(Z)-2-({[(1Z)-[(E)-2-[(2-Hy-droxy-phen-yl)methyl-idene]hydrazin-1-yl-idene]({[(4-methyl-phen-yl)meth-yl]sulfan-yl})meth-yl]disulfan-yl}({[(4-methyl-phen-yl)meth-yl]sulfan-yl})methyl-idene)hydrazin-1-yl-idene]meth-yl]phenol: crystal structure, Hirshfeld surface analysis and computational study.

Project description:The complete mol-ecule of the title hydrazine carbodi-thio-ate derivative, C32H30N4O2S4, is generated by a crystallographic twofold axis that bis-ects the di-sulfide bond. The mol-ecule is twisted about this bond with the C-S-S-C torsion angle of 90.70?(8)° indicating an orthogonal relationship between the symmetry-related halves of the mol-ecule. The conformation about the imine bond [1.282?(2)?Å] is E and there is limited delocalization of ?-electron density over the CN2C residue as there is a twist about the N-N bond [C-N-N-C torsion angle = -166.57?(15)°]. An intra-molecular hydroxyl-O-H?N(imine) hydrogen bond closes an S(6) loop. In the crystal, methyl-ene-C-H??(tol-yl) contacts assemble mol-ecules into a supra-molecular layer propagating in the ab plane: the layers stack without directional inter-actions between them. The analysis of the calculated Hirshfeld surfaces confirm the importance of H?H contacts, which contribute 46.7% of all contacts followed by H?C/C?H contacts [25.5%] reflecting, in part, the C-H??(tol-yl) contacts. The calculation of the inter-action energies confirm the importance of the dispersion term and the influence of the stabilizing H?H contacts in the inter-layer region.

| S-EPMC7405575 | biostudies-literature

3-Chloro-N'-[(2-meth-oxy-naphthalen-1-yl)methyl-idene]benzohydrazide.

Project description:The title compound, C(19)H(15)ClN(2)O(2), was prepared by the reaction of 2-meth-oxy-1-naphthaldehyde with 3-chloro-benzohydrazide in methanol. The dihedral angle between the benzene ring and the naphthyl ring system is 69.0?(3)°. In the crystal, inter-molecular N-H?O hydrogen bonds link the mol-ecules into chains along the c axis. The crystal packing exhibits ?-? inter-actions, as indicated by distances of 3.768?(3)?Å between the centroids of the naphthyl rings of neighbouring mol-ecules.

| S-EPMC3051782 | biostudies-literature

{[(1Z)-3-Chloro-1H-isoindol-1-yl-idene]meth-yl}dimethyl-amine.

Project description:The asymmetric unit of the title compound, C11H11ClN2, contains two almost-planar independent mol-ecules: the isoindole and dimethyl-amino-methyl-ene mean planes in the two mol-ecules form dihedral angles of 5.45?(8) and 1.34?(8)°. The crystal packing exhibits no short inter-molecular contacts, except for a relatively short Cl?Cl distance of 3.4907?(7)?Å.

| S-EPMC3588530 | biostudies-literature

Ethyl 2-chloro-[2-(4-chloro-phen-yl)hydrazin-1-yl-idene]acetate.

Project description:The title compound, C(10)H(10)Cl(2)N(2)O(2), features a planar C(ar)-N(H)-N=C(Cl) unit [torsion angle = 5.5 (4)°] whose benzene substituent is coplanar with it [dihedral angle = 4.7 (4)°]; this unit is slightly twisted with respect to the carboxyl -CO(2) fragment [dihedral angle = 2.2 (52)°]. The amino group acts as a hydrogen-bond donor to the carbonyl O atom of an adjacent mol-ecule; the hydrogen bond generates a helical polymer that runs along the b axis of the monoclinic unit cell.

| S-EPMC3007972 | biostudies-literature

N'-[(1E,2E)-1-(2-Phenyl-hydrazin-1-yl-idene)-1-(phenyl-sulfon-yl)propan-2-yl-idene]benzohydrazide.

Project description:The configuration about each C=N bond in the title compound, C(22)H(20)N(4)O(3)S, is E. While to a first approximation the phenyl-hydrazin-1-yl-idene and benzohydrazide residues are coplanar, in part due to the presence of an intra-molecular N-H?N hydrogen bond, significant twists are evident in the orientations of the hydrazine [N-N-C-C torsion angle = -170.74?(11)°] and benzoyl benzene [N-C-C-C = -21.72?(18)°] rings. The sulfonyl benzene ring occupies a position almost normal to the rest of the mol-ecule [C-S-C-N = -92.28?(10)°]. Centrosymmetric aggregates mediated by pairs of hydrazide-sulfonyl N-H?O hydrogen bonds are the predominant packing motif in the crystal. These are connected into linear supra-molecular chains via C-H?O inter-actions which are, in turn, linked into layers in the ac plane via C-H?? inter-actions. Connections between layers along the b-axis direction are of the ?-? type and occur between centrosymmetrically related hydrazine-bound benzene rings [centroid-centroid separation = 3.7425?(9)?Å].

| S-EPMC3200681 | biostudies-literature

2-Chloro-3-[(E)-(hydrazin-1-yl-idene)meth-yl]-6-meth-oxy-quinoline.

Project description:In the title compound, C(11)H(10)ClN(3)O, the quinoline ring system is essentially planar, the r.m.s. deviation for the non-H atoms being 0.014?(2)?Å with a maximum deviation from the mean plane of 0.0206?(14)?Å for the C atom bonded to the -CH-N=NH(2) group. In the crystal, molecules are linked via N-H?O and N-H?N hydrogen bonds, forming zigzag layers parallel to (010).

| S-EPMC3344647 | biostudies-literature

Ethyl (2E)-2-(2H-1,3-benzodioxol-5-yl-methyl-idene)-4-chloro-3-oxobutano-ate.

Project description:In the title compound, C(14)H(13)ClO(5), the five-membered ring is in an envelope conformation with the methyl-ene C-atom being the flap. The conformation about the C=C double bond [1.341?(2)?Å] is E. The chloro-propan-2-one residue is approximately orthogonal to the remaining mol-ecule [dihedral angle = 88.03?(6)°]. In the crystal, the mol-ecules associate via C-H?O inter-actions, involving both carbonyl-O atoms, giving rise to an undulating two-dimensional array in the ac plane.

| S-EPMC3089165 | biostudies-literature

(2E)-2-[2-(4-Chloro-phen-yl)hydrazin-1-yl-idene]-4,4,4-trifluoro-3-oxobutanal.

Project description:The title compound, C(10)H(6)ClF(3)N(2)O(2), was synthesized by coupling 4-dimethyl-amino-1,1,1-trifluoro-but-3-en-2-one with 4-chloro-benzene-diazo-nium chloride. It crystallizes with two mol-ecules in the asymmetric unit, which form two similar centrosymmetric dimers via hydrogen bonds. Extensive electron delocalization and intra-molecular N-H?O hydrogen bonds are responsible for a planar conformation of the mol-ecules (maximum deviations = 0.010 and -0.015?Å for the two molecules). In addition to hydrogen bonds, ?-? stacking inter-actions with centroid-centroid distances of 3.604?(2) and 3.583?(2)?Å contribute to the stability of the crystal structure.

| S-EPMC3007078 | biostudies-literature

(2E)-1-[2,3-Dichloro-6-methyl-5-(trifluoro-meth-yl)phen-yl]-2-(1-phenyl-ethyl-idene)hydrazine.

Project description:The title compound, C(16)H(13)Cl(2)F(3)N(2), exists in an E conformation with respect to the C=N bond [1.2952?(11)?Å] and the C-N-N=C torsion angle is 175.65?(8)°. The dihedral angle between the benzene rings is 42.09?(4)°. An intra-molecular C-H?F hydrogen bond generates an S(6) ring. In the crystal, the mol-ecules are linked into [101] chains by C-H?F hydrogen bonds.

| S-EPMC3515280 | biostudies-literature

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