Ontology highlight
ABSTRACT:
SUBMITTER: Sakkiah S
PROVIDER: S-EPMC3344271 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Sakkiah Sugunadevi S Meganathan Chandrasekaran C Sohn Young-Sik YS Namadevan Sundaraganesan S Lee Keun Woo KW
International journal of molecular sciences 20120423 4
11β-Hydroxysteroid dehydrogenase type1 (11βHSD1) regulates the conversion from inactive cortisone to active cortisol. Increased cortisol results in diabetes, hence quelling the activity of 11βHSD1 has been thought of as an effective approach for the treatment of diabetes. Quantitative hypotheses were developed and validated to identify the critical chemical features with reliable geometric constraints that contribute to the inhibition of 11βHSD1 function. The best hypothesis, Hypo1, which contai ...[more]